Cutaneous squamous cell carcinoma is associated with Lynch syndrome: widening the spectrum of Lynch syndrome‐associated tumours
نویسندگان
چکیده
Dear Editor, Lynch syndrome (LS) is caused by a germline mutation in one of the mismatch repair (MMR) genes. Individuals with LS have an increased risk developing colorectal and many other tumours including skin tumours.1 Sebaceous neoplasms keratoacanthomas are associated LS, also known as Muir-Torre syndrome. For cutaneous squamous cell carcinoma (SCC), association has been suggested.
منابع مشابه
Adrenocortical carcinoma is a lynch syndrome-associated cancer.
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Patients with Lynch Syndrome are at high risk for developing a variety of cancers including cancers of the colon or rectum, small bowel, stomach, uterus, renal pelvis, ureter, biliary tract, ovaries, brain and pancreas (N Engl J Med 348: 919-32, 2003; Gut 57:1097-101, 2008; NCCN, Inc Guideline. Ft. Washington, PA. Online Version 2.2014). Lack of MLH-1 and MSH-2 expression commonly result from g...
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ژورنال
عنوان ژورنال: British Journal of Dermatology
سال: 2021
ISSN: ['1365-2133', '0007-0963']
DOI: https://doi.org/10.1111/bjd.20139